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International journal of clinical and medical case studies (ISSN: 3067-3852)

International Journal of Clinical and Medical Case Studies is a peer-reviewed, open-access journal that focuses on the publication of insightful, real-world case studies that contribute to the advancement of medical science and clinical practice. By highlighting unique and rare clinical cases, the journal provides healthcare professionals and researchers with the opportunity to share critical observations and medical breakthroughs, fostering a deeper understanding of complex conditions.

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Latest Articles

Case Report

Ameloblastic carcinoma - malignant variant of a most unusual odontogenic tumor

Jerry E Bouquot, DDS, MSD, DABOMP, DABOM(Hon)*; Lakshmi Garladinne, BDS, MS; Melissa Luna, BDS, MS

The ameloblastoma, first reported as an "odontome" in 1827, has long been known as one of the most unusual and complex of odontogenic tumors, with a variety of clinical and microscopic types (Table 1) [1,2]. By 1928 it became clear that this benign, locally aggressive neoplasm with its large growth potential had an additional unique feature.

Case Report

A second case of effective eradication of alopecia areata following treatment with the dopaminergic drug dextroamphetamine

Naomi Ganpo-Nkwenkwa, BS; Jerome H Check, MD, PhD*

In contrast to alopecia related to conversion of terminal hairs to vellus hairs on a genetic/hormonal basis, Alopecia Areata (AA) is considered to have an inflammatory basis with psychogenetic and possible genetic contribution. Thus, most treatments that have been tried for AA have been attempts to interrupt the inflammatory pathways.

Case Report

Hypersensitivity reaction to selpercatinib in a patient with RET fusion-positive lung adenocarcinoma and testicular metastasis

Sheherezade Gallego-Nieto, MD; Selma Avdic; Vilma Pacheco-Barcia, PhD, MD; Sara Custodio-Cabello, MD, PhD; Magda Palka-Kotlowska, MD; Beatriz Chacón- Ovejero; José Ramón Sevilla-Resúa1; Luis Cabezón-Gutiérrez, MD, PhD*

Non-Small Cell Lung Cancer (NSCLC) frequently harbors actionable genetic alterations, including RET fusions, which occur in 1–2% of cases, predominantly in adenocarcinomas. Selpercatinib, a selective RET inhibitor, has significantly improved outcomes in these patients, demonstrating high response rates even following prior therapies.

Review Article

The relationship between diminished ovarian reserve and the increased cellular permeability syndrome

Jerome H Check, MD, PhD; Madison Neulander, BS; Diane L Check, BS; Megan McDonald-O'Neil, MS; Carrie Wilson BS

The purpose of this review and perspective is to discuss the most recent reviews of causation and treatment, with the goal of conception, of women with diminished ovarian reserve and Premature Ovarian Failure (POF). The perspective part of this review will provide our opinion on the suggested etiologies.

Case Report

Adult B-cell acute lymphocytic leukemia associated with osteolysis, but normal hematologic parameters – Rare case or related to treatment with mifepristone

Jerome H Check, MD, Phd*

Though the presence of bone pain is common in children with Acute Lymphocytic Leukemia (ALL), it is uncommon in adults. A case is presented where CT-scan to evaluate back pain led to a biopsy and diagnosis of ALL. Though 95% of the marrow was replaced by lymphoblasts, perhaps this early diagnosis was the reason why all blood hematologic parameters were completely normal.

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