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International journal of clinical and medical case studies (ISSN: 3067-3852)

International Journal of Clinical and Medical Case Studies is a peer-reviewed, open-access journal that focuses on the publication of insightful, real-world case studies that contribute to the advancement of medical science and clinical practice. By highlighting unique and rare clinical cases, the journal provides healthcare professionals and researchers with the opportunity to share critical observations and medical breakthroughs, fostering a deeper understanding of complex conditions.

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Latest Articles

Case Report

Successful live birth with cryopreserved sperm in a severe oligoasthenoteratozoospermia (OAT) patient using PVP-channel sperm selection technique

Savni Sawant*; Dr. Anuja Choudhary

In patients with severe OAT, sperm selection for Intracytoplasmic Sperm Injection (ICSI) poses a significant challenge due to extremely low sperm count, poor motility, and high levels of morphological abnormalities.

Case Series

Strong multi-sibling presence of manifestations of the condition called the increased cellular permeability syndrome without parental presence adds confusion to the mechanism of inheritance in polygenic disorders

Jerome H Check*; Naomi Ganpo-Nkwenkwa

The increased cellular permeability syndrome related to relative dopamine deficiency allowing infiltration of unwanted irritants into various tissues may be the most common cause of a great number of chronic disorders including pain or organ dysfunction.

Case Report

Ameloblastic carcinoma - malignant variant of a most unusual odontogenic tumor

Jerry E Bouquot, DDS, MSD, DABOMP, DABOM(Hon)*; Lakshmi Garladinne, BDS, MS; Melissa Luna, BDS, MS

The ameloblastoma, first reported as an "odontome" in 1827, has long been known as one of the most unusual and complex of odontogenic tumors, with a variety of clinical and microscopic types (Table 1) [1,2]. By 1928 it became clear that this benign, locally aggressive neoplasm with its large growth potential had an additional unique feature.

Case Report

A second case of effective eradication of alopecia areata following treatment with the dopaminergic drug dextroamphetamine

Naomi Ganpo-Nkwenkwa, BS; Jerome H Check, MD, PhD*

In contrast to alopecia related to conversion of terminal hairs to vellus hairs on a genetic/hormonal basis, Alopecia Areata (AA) is considered to have an inflammatory basis with psychogenetic and possible genetic contribution. Thus, most treatments that have been tried for AA have been attempts to interrupt the inflammatory pathways.

Case Report

Hypersensitivity reaction to selpercatinib in a patient with RET fusion-positive lung adenocarcinoma and testicular metastasis

Sheherezade Gallego-Nieto, MD; Selma Avdic; Vilma Pacheco-Barcia, PhD, MD; Sara Custodio-Cabello, MD, PhD; Magda Palka-Kotlowska, MD; Beatriz Chacón- Ovejero; José Ramón Sevilla-Resúa1; Luis Cabezón-Gutiérrez, MD, PhD*

Non-Small Cell Lung Cancer (NSCLC) frequently harbors actionable genetic alterations, including RET fusions, which occur in 1–2% of cases, predominantly in adenocarcinomas. Selpercatinib, a selective RET inhibitor, has significantly improved outcomes in these patients, demonstrating high response rates even following prior therapies.

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