Unilateral scabies in a 6-week-old infant
Hannah P Hannert*; Martin Zikeli; Robert R Müllegger
We report the case of a 6-week-old female who, since the 4th week of life, developed red papules and papulovesicles beginning at the left elbow and spreading unilaterally. There was no involvement of the face, scalp, palms and feet.
Risk and screening of stomach cancer in patients with Biermer’s disease: A clinical and scientific review
Emmanuel Andrès*; Jean Edouard Terrade; Maria Belén Alonso Ortiz; Xavier Jannot; Manuel Méndez Bailón; Gérard Gay; Thierry Lavigne; N Lorenzo-Villalba
Biermer’s disease, or pernicious anemia, is an autoimmune atrophic gastritis characterized by the destruction of gastric parietal cells, a deficiency in intrinsic factor, and a lack of vitamin B12. Although widely recognized for its hematological and neurological effects, this disease also constitutes a high-risk environment for the development of neoplasms.
The relative efficacy of three different dopamine agonists in relieving symptoms of various manifestations of the increased cellular permeability syndrome: Case report
Jerome H Check, MD, PhD*; Priya Srivastava; Carolyn Kelley
There is evidence that a high percentage of chronic medical disorders have as the initiating etiology a defect in the mucosal barrier of a given tissue leading to infiltration of unwanted toxic elements which results in inflammation pain or organ dysfunction related to unwanted elements altering mitochondria or nerve pathways.
Radioiodine treatment of patients with graves hyperthyroidism – What should patients be told about its effects on the eyes
Hooshang Lahooti, BSc, PhD; Bernard Champion, MBBS, MMed, FRACP; Jack R Wall, MD, PhD, FRACP, FRCPC*
Many studies have shown that existing eye disease (ophthalmopathy) often worsens following Radioiodine (RAI) treatment of Graves hyperthyroidism. The development of new- onset eye disease is very uncommon.
Involvement of galectin-1 in the prolonged hypotensive effect induced by mandibular extension in spontaneously hypertensive rats
Giuseppe Federighi†*; Laura Sabatino†; Dominga Lapi; Cristina Del Seppia; Rossana Scuri
Two 10-minute openings of the mouth obtained with a spring device called mandibular extension applied at 10-minute intervals (2-ME treatment) induce a hypotensive effect in Spontaneously Hypertensive Rats (SHRs), producing a vasodilation previously observed in cortical parietal pial vascular districts.
Blood transfusion: What to transfuse?
Cees Th Smit Sibinga, MD, PhD, FRCP Edin, FRCPath*
Physiology learns the function of organs like liver and bone marrow. In case of disturbed balances these organs are stimulated to increase their function and strengthen their metabolic processes like protein synthesis and blood cell production and release. These processes are time dependent to compensate loss.
Is there a future for therapeutic peptides to aid, benefit, and treat cancer in adults? A review and commentary
Gerald J Mizejewski*
This study addresses a topic concerning the use of therapeutic amphipathic antimicrobial-like peptides in the course of treating adult cancer such as breast malignancies. As a peptide example for this report, a naturally occurring pregnancy protein derived peptide was selected to demonstrate its biochemical
Chemotherapy-responsive hepatocellular carcinoma cell lines in organoid systems: Advances and clinical applications
Seung Hoon Lee*
Hepatocellular Carcinoma (HCC) remains a challenging malignancy with poor prognosis despite therapeutic advances. Although immunotherapy has gained attention, chemotherapy continues to play a central role in systemic treatment, particularly in advanced or drug-resistant disease.
A second case of palmoplantar eczema effectively ameliorated following treatment with the dopamine agonist dextroamphetamine sulfate
Jerome H Check, MD, PhD*
Palmoplantar eczema (previously referred to as dyshidrotic eczema related to its usual presentation of clear fluid filled intraepidermal vesicles) typically presents on the hands and the feet. These vesiculobullous lesions sometimes give
The first case demonstrating marked amelioration of severe restless legs syndrome following treatment with the dopamine agonist dextroamphetamine sulfate
Jerome H Check, MD, PhD*; Diane L Check, BS; Priya Srivastava
The standard treatment for Restless Legs Syndrome (RLS) are dopamine agonist drugs e.g., pramipexole and ropinirole. There are a great number of drugs that are not dopamine agonists that have proven effective for RLS.
Robotic enucleation for large inflammatory myoblastic tumour: A safe, margin-conscious approach to maximise bladder Preservation
Ibrahim Y*; Gad M; Mokbel S; Nair R; Thurairaja R; Khan S
Inflammatory Myofibroblastic Tumour (IMT) of the bladder is a rare mesenchymal neoplasm with low malignant potential. While typically managed with organ-sparing surgery, large or exophytic lesions pose a challenge due to the risk of bleeding, local progression, and potential infiltration of adjacent structures.
Dopaminergic drugs for treating chronic rhinosinusitis developing as a post coronavirus disease (COVID) complication
Jerome H Check, MD, PhD*; Tammy Citerone, RN
Chronic rhinosinusitis can exist with or without nasal polyps. Evidence supports that the pathophysiology may be related to an epithelial barrier dysfunction leading to infiltration of unwanted elements that stimulate an inflammatory response.
Voluntary amputation of a healthy limb - what do affected patients expect from the operation?
Stephanie Herr; Erich Kasten, PhD*
There are people who suffer from the desire to have a leg or arm amputated. Only after removing of a limb the external body corresponds to their mental body image. Previous psychotherapeutic or psychopharmacological therapies have not been able to cure this condition.
Nodular fasciitis in a child: A case report of an unusual localisation and literature review
Djeradi Ahyee, MD, MS*; Wassom Patrick, MD; Beaudelaire Romulus Assan, MD, Msc; Karl Ebassa, MD; Jacques Sommier, MD; Marc Janoyer, MD; Cecilia Tolg, MD
We report a rare case of nodular fasciitis in a 12 years old boy. He noticed a rapidly growing swelling in the left supraclavicular region over 6 months. MIR of the shoulder showed a well-limited oval tissue mass within the insertion of the trapezius muscle on the clavicle, taking contrast after gadolinium injection with no signal abnormalities in muscle and bone tissue.
Bridging the gap: Integrating the endocannabinoid system into medical education
Stefan Broselid, MSc, PhD; Shiksha Gallow, PhD, DMed, MMedSci, MPH, MBA*
This study addresses the critical gap in medical education concerning the Endocannabinoid System (ECS), a key component of physiological regulation absent from standard medical curricula. Despite its discovery in 1992 and its established role in maintaining homeostasis, the ECS is largely ignored in medical training, affecting patient care, therapeutic development, and clinicians' grasp of physiology.
Skin cancer classification using VGG-16
Tanvir Mahmud*; SA Sabbirul Mohosin Naim; Prajoy Podder
Skin cancer with a high fatality rate is called melanoma. Due to the great degree of similarities among the many forms of skin lesions, a proper diagnosis cannot be made. Dermatologists can treat patients and save their lives by accurately classifying skin lesions in their early stages. This paper proposes a model for highly accurate skin lesion classification.
Hemothorax from bleeding paraesophageal varices: A rare complication of cirrhosis
Meghan Woodsum; Kevin Huang; Anupma Jati; H Christian Weber*
Spontaneous hemothorax from paraesophageal variceal hemorrhage is a very rare complication of cirrhosis. Our report highlights a patient with previously compensated cirrhosis hospitalized with acute alcoholic hepatitis and newly decompensated cirrhosis. The patient developed acute hypoxic respiratory failure with new significant anemia.
Radiation recall myositis resistant to conventional therapies: Clinical improvement with botulinum toxin A intervention
Ahmet Basari*; Gungor Enver Ozgencil
Radiation Recall Myositis (RRM) is a rare phenomenon that occurs after radiotherapy and chemotherapy. Gemcitabine is the most commonly implicated agent in its development. Its classical treatment consists of discontinuation of the associated drug, corticosteroids, and analgesic drugs.
Extradural ligamentum flavum cyst: MRI characteristics and surgical management
Wassim Khalil*; Caroline Apra; Karim Chirani; Zo Miantsa Harimbonona; Fanomezantsoa Tanjona Ratovoarison; Henri Salle; Nouman Aldahak
Ligamentum Flavum Cysts (LFC) are uncommon and their differentiation from other Juxta-facetal cysts & epidural cystic lesions is difficult based on imaging techniques. We present one such rare case of ligamentum flavum cyst with relevant review of the literature.
Successful live birth with cryopreserved sperm in a severe oligoasthenoteratozoospermia (OAT) patient using PVP-channel sperm selection technique
Savni Sawant*; Dr. Anuja Choudhary
In patients with severe OAT, sperm selection for Intracytoplasmic Sperm Injection (ICSI) poses a significant challenge due to extremely low sperm count, poor motility, and high levels of morphological abnormalities.
Strong multi-sibling presence of manifestations of the condition called the increased cellular permeability syndrome without parental presence adds confusion to the mechanism of inheritance in polygenic disorders
Jerome H Check*; Naomi Ganpo-Nkwenkwa
The increased cellular permeability syndrome related to relative dopamine deficiency allowing infiltration of unwanted irritants into various tissues may be the most common cause of a great number of chronic disorders including pain or organ dysfunction.
Ameloblastic carcinoma - malignant variant of a most unusual odontogenic tumor
Jerry E Bouquot, DDS, MSD, DABOMP, DABOM(Hon)*; Lakshmi Garladinne, BDS, MS; Melissa Luna, BDS, MS
The ameloblastoma, first reported as an "odontome" in 1827, has long been known as one of the most unusual and complex of odontogenic tumors, with a variety of clinical and microscopic types (Table 1) [1,2]. By 1928 it became clear that this benign, locally aggressive neoplasm with its large growth potential had an additional unique feature.
A second case of effective eradication of alopecia areata following treatment with the dopaminergic drug dextroamphetamine
Naomi Ganpo-Nkwenkwa, BS; Jerome H Check, MD, PhD*
In contrast to alopecia related to conversion of terminal hairs to vellus hairs on a genetic/hormonal basis, Alopecia Areata (AA) is considered to have an inflammatory basis with psychogenetic and possible genetic contribution. Thus, most treatments that have been tried for AA have been attempts to interrupt the inflammatory pathways.
Hypersensitivity reaction to selpercatinib in a patient with RET fusion-positive lung adenocarcinoma and testicular metastasis
Sheherezade Gallego-Nieto, MD; Selma Avdic; Vilma Pacheco-Barcia, PhD, MD; Sara Custodio-Cabello, MD, PhD; Magda Palka-Kotlowska, MD; Beatriz Chacón- Ovejero; José Ramón Sevilla-Resúa1; Luis Cabezón-Gutiérrez, MD, PhD*
Non-Small Cell Lung Cancer (NSCLC) frequently harbors actionable genetic alterations, including RET fusions, which occur in 1–2% of cases, predominantly in adenocarcinomas. Selpercatinib, a selective RET inhibitor, has significantly improved outcomes in these patients, demonstrating high response rates even following prior therapies.
The relationship between diminished ovarian reserve and the increased cellular permeability syndrome
Jerome H Check, MD, PhD; Madison Neulander, BS; Diane L Check, BS; Megan McDonald-O'Neil, MS; Carrie Wilson BS
The purpose of this review and perspective is to discuss the most recent reviews of causation and treatment, with the goal of conception, of women with diminished ovarian reserve and Premature Ovarian Failure (POF). The perspective part of this review will provide our opinion on the suggested etiologies.
Adult B-cell acute lymphocytic leukemia associated with osteolysis, but normal hematologic parameters – Rare case or related to treatment with mifepristone
Jerome H Check, MD, Phd*
Though the presence of bone pain is common in children with Acute Lymphocytic Leukemia (ALL), it is uncommon in adults. A case is presented where CT-scan to evaluate back pain led to a biopsy and diagnosis of ALL. Though 95% of the marrow was replaced by lymphoblasts, perhaps this early diagnosis was the reason why all blood hematologic parameters were completely normal.
Non-carious lesions: A modern condition that can affect teeth
Carolina dos Santos Santinoni*; Ana Paula Varela Brown Martins; Juliana Silva Ribeiro De Andrade; Mauricio Malheiros Badaró; Sheila Cristina Stolf Cupani; Thais Mageste Duque
The decrease in the prevalence of caries and periodontal disease, as well as the aging of the world's population, has increased the number of cases of diseases unrelated to the presence of microorganisms, such as cervical dentin hypersensitivity and Non-Carious Lesions (NCL) [1].
Dental management of HIV positive patients
Carolina dos Santos Santinoni*; Gabriel Leonardo Magrin; Bernardo Born Passoni; Ariadne Cristiane Cabral da Cruz; Marco Aurélio Bianchini; Gláucia Santos Zimmermann; Cesar Augusto Magalhães Benfatti; Ricardo de Souza Magini
The medications used by these patients can cause side effects, manifestations in the oral cavity and interact with drugs used by the dentist, interfering with the dental treatment plan [1]. Antiretrovirals (ARVs) are used not only to treat the infection but also as a strategy to prevent it in various situations.
How nitroxide-restricted endothelial function contributes to the development of acute lung abscess
Muhammad Salman Malik; Abu Huraira; Abdul Rehman; Muhammad Abuzar Fahim; Abdullah Bin Aamer; Arsalan Khalid; Hira Ashiq; Muhammad Waqar Mazhar*
Among the leading causes of infection and mortality worldwide, purulent-destructive lung diseases continue to rank high. Impairment of this organ's barrier-filtration function, based on endothelial dysfunction, may be connected with the key to infection development in acute lung abscesses.
Comprehensive nursing's effects on diabetic children's quality of life, nod-like receptor protein 3 levels, and inflammatory cytokines
Bakhtawar Imtiaz; Muhammad Moosa Qureshi; Ifra Mehmood; Mesum Ali Khan; Muhammad Noman; Rizwan Abbas; Faisal Muzaffar; Muhammad Waqar Mazhar*
Our goal was to find out how comprehensive nursing care affected the children with diabetes's quality of life and inflammatory cytokine levels. Fifty-eight children with diabetes who were hospitalized to our hospital participated in a control study.
Unraveling hematological and coagulation pattern in malaria: A study from Kassala city, Eastern Sudan
Mohammed Mustafa Hassan; Bashir A Bashir*
Malaria continues to pose a significant public health concern in Eastern Sudan. This study assesses the hematological parameters and coagulation profile among malaria-infected patients in Kassala City. The disease, caused by Plasmodium parasites and transmitted through the bite of infected Anopheles mosquitoes, leads to significant morbidity and mortality.
Measurement to the paraumbilical perforator of deep inferior epigastric artery and estimation of its anatomical boundary by color ultrasound
Liu Xiao-Jun; Yi Xue-Ting; Shi Min; Zhang Jun; Su Jian-Dong*
To investigate the distinguishment of paraumbilical perforator of Deep Inferior Epigastric Artery (DIEA) between the diabetics and normal patients and estimate its anatomical district by color doppler ultrasound.
What can we learn from case reports?
Jitong Zhao*
Case reports are an important part of medical research, typically describing the unique diagnoses, treatment processes, and follow-up results of individual patients. They not only provide us with deep insights into diseases but also serve as significant resources for clinical practice, education, and research.
A rare presentation of extrapulmonary small cell cancer with bone involvement: Case report and insight into clinical management
Hiep Nguyen*; Rama Koya; Vinh Nguyen
Extrapulmonary Small Cell Carcinoma (EPSCC) is a rare and aggressive malignancy that shares histopathological features with small cell lung cancer but originates outside the lungs. Bone metastasis in EPSCC, especially involving the spine, pelvis, and ribs, is common and correlates with poor prognosis.
Laparoscopic non-tension hernioplastic of lower lumbar hernia
Igor Černi, MD, MS*
Lumbar or petit hernia is a rare condition, traditional open operative treatment with reparation of hernia opening and surrounding tissue is difficult, painful, and with uncertain outcome.
Two cases of "IRIS" with syphilis
Murugan Sankaranantham
Immune Reconstitution Syndrome (IRIS) in HIV management is not uncommon. It is a state of hyperinflammatory response that usually occurs in the first six months of treatment of HIV/AIDS patient, following HAART. Co-infection of syphilis in HIV disease is so common.
Beyond the surface- When anatomy goes awry: A deep dive into gastric anomalies- Insight from a unique case
Nayab Mustansar*; Col Tariq Saeed Siddiqui; Col Asma Asghar; Aaisha Shafiq; Atta Ur Rahman; Haider
We present the case of a 37-year-old female with gastric fullness and early satiety. Imaging revealed a metallic object in the stomach, leading to a Contrast-Enhanced CT scan (CECT) that demonstrated non-rotation of the gut, an annular pancreas, and a duodenal web, resulting in significant duodenal dilatation.
Investigating the challenges and opportunities of telemedicine in enhancing health care access in Nigeria
Agbeni Kehinde Emmanuel*; Sulaimon Olajuwon Abdul; Daniel Ebubechi Obasi; Peterkings Eriuroro Jokoh; Efoghe Magdalene Omoze; Akon Ekpenyong Usoh; Abdullahi Aderemi Ashimi; Ayobami Abdurazak Adisa
The study examines the challenges and opportunities of telemedicine in health care delivery in Nigeria at a point that healthcare delivery has a long significant challenges. The study adopts cross sectional research design. Furthermore, the research method for this study is survey.
Pharmaceutical market access and drug affordability in low-income nations
Agbeni Kehinde Emmanuel*; Sulaimon Olajuwon Abdul; Daniel Ebubechi Obasi; Peterkings Eriuroro Jokoh; James Hamman Malgwi; Ayobami Abdurazak Adisa; Abdullahi Aderemi Ashimi
The pharmaceutical industry is going through a paradigm shift, and the dynamics of the sector are increasingly being shaped by emerging markets. The study aimed at examining the impact of regulation of distribution chains and tariff/tax exemptions on pharmaceutical market access and drug affordability in low-income countries.
Bifurcation analysis and multiobjective nonlinear model predictive control of drug addiction models
Lakshmi N Sridhar*
Bifurcation analysis and nonlinear model predictive control were performed on drug addiction models. Rigorous proof showing the existence of bifurcation (branch) points is presented along with computational validation.
Familial adenomatous polyposis: A case report
Huan Nguyen Ngoc*
Colon polyps, which are atypical growths on the colonic lining, exhibit significant variability in size, morphology, and risk for malignancy. Although numerous polyps are nonmalignant, several types possess the capacity to progress into colorectal cancer over time.